Gene therapy represents a promising approach to treating genetic disorders, but several challenges may prevent it from being a permanent solution.
Immune Responses: The body’s immune system can recognize the introduced genes or viral vectors as foreign, potentially triggering an immune response that can diminish the therapy’s effectiveness over time. This reaction may lead to the elimination of the therapeutic agents before they can achieve lasting benefits.
Limited Duration of Gene Expression: Many gene therapies rely on temporary expression of the therapeutic gene. If the introduced gene is not maintained in the target cells, its effects may wane, necessitating repeat treatments or booster doses to sustain efficacy.
Genetic Variability: Each individual’s genetic makeup can influence how well gene therapy works. Variations in the target gene, the cellular environment, and other genetic factors can lead to inconsistent results across different patients.
Ongoing research aims to address these challenges, exploring innovative strategies to enhance the durability and effectiveness of gene therapy, with the ultimate goal of providing long-lasting solutions for patients.
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