Gene therapy shows significant promise in the treatment of fibrosis by targeting key genes, particularly TGF-β1 (transforming growth factor-beta 1), which is crucial in driving excessive scar tissue formation. Innovative techniques, such as CRISPR-Cas9, are being utilized to modify or silence the TGF-β1 gene, potentially reducing or even halting the fibrotic process.
Additionally, stem cell-based gene therapy is emerging as a strategy to regenerate healthy tissue in fibrotic areas. Adeno-associated viruses (AAVs) serve as effective vectors to deliver these genetic modifications to affected cells. Although these therapies are still in experimental stages, they provide hope for curing fibrosis by addressing the genetic drivers of this debilitating condition.
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